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UKHSA is investigating a novel cluster of Burkholderia cenocepacia

23 November 2023

UKHSA is investigating a novel cluster of Burkholderia cenocepacia involving 20 cases across the UK. Of these cases, 12 (60%) are male, 18 (90%) are adults and two are paediatric patients (age range 6 weeks – 82 years, median 57 years). 14/20 (70%) were

critical care inpatients. Two patients have cystic fibrosis (CF). Preliminary epidemiological and microbiological investigations have identified a potential association with carbomer containing lubricating eye gel, though investigations are ongoing and these findings are not conclusive.

As a precautionary measure until further information is available, it is recommended that carbomer-containing lubricating eye gels for dry eyes are avoided where possible in the following groups:

  1. individuals with CF;
  2. critical care inpatients;
  3. severely immunocompromised inpatients; and
  4. patients awaiting lung transplantation.

UKHSA is working with NHS England and CF expert stakeholders to issue communications directly to CF patients, who will be directed to their CF Treatment Centres for further clinical advice.

Please see attached letter below.

Burkholderia cenocepacia outbreak with suspected association with carbomer containing lubricating eye gel

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